How to Combat Side Effects from GLP-1 Weight Loss Medications
A Marshview Direct Primary Care guide to feeling better while losing weight
GLP-1 weight loss medications such as Wegovy or Zepbound have helped many Marshview patients lose weight, improve metabolic health, and feel more in control of their relationship with food. Medications like semaglutide- and tirzepatide-based treatments can be incredibly effective—but they’re not magic, and they’re not one-size-fits-all.
Side effects are common, especially early on or after dose increases. The good news? Most side effects are mild, temporary, and very manageable with the right support. That’s where direct primary care really shines.
Here’s how we help Marshview patients stay comfortable and successful on GLP-1 therapy.
Nausea (and Sometimes Vomiting)
This is the most common side effect we see—and the one patients worry about most.
Why it happens:
GLP-1 medications slow stomach emptying and reduce appetite. Eating too much, too quickly, or choosing heavier foods can overwhelm your system.
What helps:
Eat smaller portions and stop eating at the first sign of fullness
Slow down meals—this matters more than you think
Eat foods that contain water, like soups and gelatin
Avoid greasy, fried, or very rich foods, especially early on
Stick with bland foods if symptoms flare (eggs, yogurt, toast, rice)
Avoid lying down after you eat
Go outdoors for fresh air
Drink clear, ice-cold drinks
👉 Marshview tip: Many patients feel best making breakfast or lunch their largest meal and keeping dinner lighter.
Constipation
Very common—and very fixable.
Why it happens:
You’re eating less, digestion slows, and hydration often drops unintentionally.
What helps:
Hydration is key—most people need more fluids than they realize
Add fiber slowly through foods like berries, oats, chia seeds, and vegetables. Over the counter psyllium (such as Metamucil) can also help
Magnesium (glycinate or citrate) in the evening can be helpful
Daily movement—even a walk around the block after dinner helps stimulate the gut
We avoid “overcorrecting” with harsh laxatives unless absolutely necessary.
Diarrhea, Bloating, or GI Upset
These symptoms are often food-related.
What helps:
Reduce fatty, greasy, or highly processed foods
Watch sugar alcohols and large carb-heavy meals
Be mindful of dairy if you’re lactose sensitive
Eat regularly—skipping meals can actually worsen symptoms
At Marshview, we often identify personal trigger foods and adjust around them rather than stopping medication altogether.
Fatigue or Low Energy
This is especially common in the first few weeks.
Why it happens:
Calorie intake drops quickly, and your body is adjusting.
What helps:
Ensure adequate protein intake to preserve muscle and energy
Don’t undereat—fueling your body still matters
Add electrolytes if you’re lightheaded or fatigued
Strength training 2–3 times per week helps maintain metabolism and energy
We monitor weight loss pace closely—losing too fast isn’t the goal.
Heartburn or Acid Reflux
Often related to timing and portion size.
What helps:
Avoid eating within 2–3 hours of bedtime
Keep evening meals smaller
Limit spicy or acidic foods
Elevate the head of the bed if needed
Injection Site Issues
Bruising or irritation can happen but is usually minor.
What helps:
Rotate injection sites weekly
Let medication come to room temperature before injecting
Avoid injecting into scar tissue or irritated skin
The Most Important Strategy: Go Slow
Many side effects happen when doses are increased too quickly.
At Marshview Direct Primary Care, we:
Individualize titration schedules
Hold doses longer if side effects appear
Adjust nutrition and hydration before changing medication
Check in frequently—no waiting weeks for advice
There is no benefit to rushing. Sustainable weight loss always wins.